We engineer proteins through reductive strategies, harnessing the full potential of natural proteins to modulate interactions and build sensors.

Reductive strategies simplify the complex relationship between protein structure and function by focusing on key elements such as domains and short motifs. This enables effective exploration of the infinite protein sequence space, accelerating the identification of critical residues in proteins with desired properties.

At KIST, the Protein Engineering & Regulation Laboratory integrates protein engineering, molecular biology, and AI to deepen our understanding of molecular interactions and develop therapeutic peptides, novel binders, and high-sensitivity biosensors.

KIST 강릉 천연물신약사업단 단백질공학 및 제어 연구실(PI 서문형 박사 · 책임연구원)은 단백질공학과 분자생물학에 AI를 접목해 단백질 상호작용 규명과 제어를 통한 펩타이드 치료제와 고감도 바이오센서 개발 연구를 수행하고 있습니다.