We engineer proteins through reductive strategies, harnessing the full potential of natural proteins to modulate interactions and build sensors.

Reductive strategies simplify the complex relationship between protein structure and function by focusing on key elements such as domains and short motifs. This enables effective exploration of the infinite protein sequence space, accelerating the identification of critical residues in proteins with desired properties.

At KIST, the Protein Engineering & Regulation Laboratory integrates protein engineering, molecular biology, and AI to deepen our understanding of molecular interactions and develop therapeutic peptides, novel binders, and high-sensitivity biosensors.