Publications | 서문형 박사 연구실 · Protein Engineering & Regulation Lab @ KIST

Author key Seo MH = lab PI · * Co-corresponding or co-first author

Selected Publications

7 highlighted

2025

Massively Parallel Screening of Toll/Interleukin-1 Receptor (TIR)-Derived Peptides Reveals Multiple Toll-Like Receptors (TLRs)-Targeting Immunomodulatory Peptides

Lim Y, Kang TK, Kim MI, Kim D, Kim JY, Jung SH, Park K, Lee WB, Seo MH

Advanced Science

Adv. Sci. 12, 2406018 (2025)

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🏆 Top 10% Most-Viewed Paper · Advanced Science (2024)

Press & coverage: 동아사이언스 조선일보 중앙일보 헬로디디 BRIC 연구성과

2023

Q-SHINE: A versatile sensor for glutamine measurement via ligand-induced dimerization

Lim Y, Kim JY, Jung YH, Lee JH, Baek MS, Jung JH, Kim HY, Lee W, Park K, Seo MH

Sensors and Actuators B: Chemical

Sens. Actuators B Chem. 390, 133951 (2023)

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Press & coverage: 연합뉴스 조선일보 전자신문 대덕넷·헬로디디 메디포뉴스 KIST 보도자료

2018

A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase

Kataria M, Mouilleron S, Seo MH, Corbi C, Kim PM, Uhlmann F

Nature Structural & Molecular Biology

Nat. Struct. Mol. Biol. 25(12), 1093–1102 (2018)

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2016

Protein engineering by highly parallel screening of computationally designed variants

Sun MG*, Seo MH*, Nim S, Corbi-Verge C, Kim PM

Science Advances

Sci. Adv. 2(7), e1600692 (2016)

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2016

Pooled screening for antiproliferative inhibitors of protein–protein interactions

Nim S, Jeon J, Corbi-Verge C, Seo MH, Ivarsson Y, Moffat J, Tarasova N, Kim PM

Nature Chemical Biology

Nat. Chem. Biol. 12(4), 275–281 (2016)

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2014

Conformational dynamics of proteins dictate the binding affinity for a ligand

Seo MH, Park J, Kim E, Hohng S, Kim HS

Nature Communications

Nat. Commun. 5, 3724 (2014)

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2013

Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase

Choi JM*, Seo MH*, Kyeong HH, Kim E, Kim HS

Proceedings of the National Academy of Sciences

PNAS 110(25), 10171–10176 (2013)

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Awards & Recognition

5 awards · 2025–2026

2026

🏆 Top 10% Most-Viewed Paper

Advanced Science · Wiley

Ranked within the top 10% of most-viewed papers published in Advanced Science in 2024 — for "Massively Parallel Screening of TIR-Derived Peptides" (Adv. Sci. 2025).

2026

🥇 Best Poster Award

PepTalk 2026

2026 PepTalk 최우수 포스터상

2025

🏅 NST Chairperson's Award for Outstanding Research

National Research Council of Science & Technology (NST)

출연(연) 우수 연구성과 NST 이사장상

2025

🌟 KIST Person of the Month

Korea Institute of Science and Technology (KIST)

이달의 KIST인상

2025

🏆 Outstanding R&D Team Award

Korea Institute of Science and Technology (KIST)

KIST 우수 연구개발팀상

Press & Media

News · interviews · broadcasts

Adv. Sci. 2025 — TIR-derived peptide screening

Coverage following publication of the TIR peptide platform.

동아사이언스 Dong-A Science

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조선일보 Chosun Ilbo · Nov 2024

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중앙일보 JoongAng Ilbo

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헬로디디 HelloDD

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BRIC 한국연구재단 연구성과

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Sens. Actuators B 2023 — Q-SHINE glutamine sensor

Coverage following publication of the Q-SHINE biosensor.

연합뉴스 Yonhap News · Aug 2023

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조선일보 Chosun Ilbo · Aug 2023

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전자신문 Electronic Times

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대덕넷·헬로디디 HelloDD

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메디포뉴스 Medifonews

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KIST 보도자료 KIST Press Release

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Broadcast interviews

Television and broadcast media coverage of lab research.

YTN Science News segment · Dec 2024

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YTN Science Program feature · Dec 2024

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KIST 60주년 특집 다큐 YouTube

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건성 황반변성 점안치료제 KIST YouTube Shorts

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Interviews & authored commentary

Profile, interview coverage, and authored commentary by the PI and members.

한빛사 인터뷰 BRIC HanBitSa Interview

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짧은 펩타이드 모티프 기반 단백질 상호작용과 신약개발 동향 BRIC 동향 보고서 · 2018

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세포 속 미개척 타깃을 활용한 펩타이드 신약 개발 플랫폼 한국경제 기고 · Dec 2023

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모티프 기반 protein-protein interaction 연구 BT News 기고 · Oct 2018

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Technology transfer & licensing

Industry coverage of lab technology transfer activities.

히트뉴스 HitNews

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머니투데이 Money Today · Dec 2024

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All Publications

23 papers · 2007–2025

2025

Enhancing protein structural properties through model-guided sequence optimization

Ko YJ, Kim D, Muvva C, Lee WK, Seo MH*, Park K

International Journal of Biological Macromolecules

Int. J. Biol. Macromol. 323(Pt 1), 147072 (2025)

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Massively Parallel Screening of Toll/Interleukin-1 Receptor (TIR)-Derived Peptides Reveals Multiple Toll-Like Receptors (TLRs)-Targeting Immunomodulatory Peptides

Lim Y, Kang TK, Kim MI, Kim D, Kim JY, Jung SH, Park K, Lee WB, Seo MH

Advanced Science

Adv. Sci. 12, 2406018 (2025)

Journal page →

2024

Computational identification of key residues regulating fluorescence emission in a red/green cyanobacteriochrome

Kannan P, Oh J, Yeon YJ, Park YI, Seo MH, Park K

Proteins: Structure, Function, and Bioinformatics

Proteins Struct. Funct. Bioinforma. 92(1), 106–116 (2024)

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2023

Q-SHINE: A versatile sensor for glutamine measurement via ligand-induced dimerization

Lim Y, Kim JY, Jung YH, Lee JH, Baek MS, Jung JH, Kim HY, Lee W, Park K, Seo MH

Sensors and Actuators B: Chemical

Sens. Actuators B Chem. 390, 133951 (2023)

Journal page →

Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression

Choi H, Ju S, Kang K, Seo MH, Kim JM, Miyoshi E, Yeo MK, Park SY

Frontiers in Oncology

Front. Oncol. 13, 1–12 (2023)

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Domain-wise dissection of thermal stability enhancement in multidomain proteins

Oh J, Durai P, Kannan P, Park J, Yeon YJ, Lee WK, Park K, Seo MH

International Journal of Biological Macromolecules

Int. J. Biol. Macromol. 237, 124141 (2023)

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A conformation-selective protein binder for a KRAS mutant inhibits the interaction between RAS and RAF

Jung YH, Choi Y, Seo HD, Seo MH*, Kim HS*

Biochemical and Biophysical Research Communications

Biochem. Biophys. Res. Commun. 645, 110–117 (2023)

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2021

Anti-staphylococcal activity of a cyclic lipopeptide, C15-bacillomycin D, produced by Bacillus velezensis NST6

Nam J, Alam ST, Kang K, Choi J, Seo MH

Journal of Applied Microbiology

J. Appl. Microbiol. 131, 93–104 (2021)

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2020

Complete genome sequence of Bacillus velezensis NST6 and comparison with the species belonging to operational group B. amyloliquefaciens

Choi J, Nam J, Seo MH

Genomics

Genomics 113(1 Pt 1), 380–386 (2020)

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2018

A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase

Kataria M, Mouilleron S, Seo MH, Corbi C, Kim PM, Uhlmann F

Nature Structural & Molecular Biology

Nat. Struct. Mol. Biol. 25(12), 1093–1102 (2018)

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The present and the future of motif-mediated protein-protein interactions

Seo MH, Kim PM

Current Opinion in Structural Biology

Curr. Opin. Struct. Biol. 50, 162–170 (2018)

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2017

Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome

Davey NE*, Seo MH*, Yadav VK*, Jeon J, Nim S, Krystkowiak I, Blikstad C, Dong D, Markova N, Kim PM, Ivarsson Y

FEBS Journal

FEBS J. 284, 485–498 (2017)

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Large-Scale Interaction Profiling of Protein Domains Through Proteomic Peptide-Phage Display Using Custom Peptidomes

Seo MH, Nim S, Jeon J, Kim PM

Methods in Molecular Biology

Methods Mol. Biol. 1518, 213–226 (2017)

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2016

Protein engineering by highly parallel screening of computationally designed variants

Sun MG*, Seo MH*, Nim S, Corbi-Verge C, Kim PM

Science Advances

Sci. Adv. 2(7), e1600692 (2016)

Journal page →

Pooled screening for antiproliferative inhibitors of protein-protein interactions

Nim S, Jeon J, Corbi-Verge C, Seo MH, Ivarsson Y, Moffat J, Tarasova N, Kim PM

Nature Chemical Biology

Nat. Chem. Biol. 12(4), 275–281 (2016)

Journal page →

2014

Conformational dynamics of proteins dictate the binding affinity for a ligand

Seo MH, Park J, Kim E, Hohng S, Kim HS

Nature Communications

Nat. Commun. 5, 3724 (2014)

Journal page →

2013

Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase

Choi JM*, Seo MH*, Kyeong HH, Kim E, Kim HS

Proceedings of the National Academy of Sciences

PNAS 110(25), 10171–10176 (2013)

Journal page →

Simple and efficient strategy for site-specific dual labeling of proteins for single-molecule FRET analysis

Kim J*, Seo MH*, Lee S, Cho K, Yang A, Woo K, Kim HS, Park HS

Analytical Chemistry

Anal. Chem. 85(3), 1468–1474 (2013)

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2012

Insignificant role of the N-terminal cobalt-binding site of albumin in the assessment of acute coronary syndrome: discrepancy between the albumin cobalt-binding assay and N-terminal-targeted immunoassay

Oh BJ, Seo MH, Kim HS

Biomarkers

Biomarkers 17(5), 394–401 (2012)

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2011

Efficient single-molecule fluorescence resonance energy transfer analysis by site-specific dual-labeling of protein using an unnatural amino acid

Seo MH, Lee TS, Kim E, Cho YL, Park HS, Yoon TY, Kim HS

Analytical Chemistry

Anal. Chem. 83(23), 8849–8854 (2011)

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Controlled and oriented immobilization of protein by site-specific incorporation of unnatural amino acid

Seo MH, Han J, Jin Z, Lee DW, Park HS, Kim HS

Analytical Chemistry

Anal. Chem. 83(8), 2841–2845 (2011)

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2009

Designing the substrate specificity of d-hydantoinase using a rational approach

Lee S, Chang Y, Shin DM, Han J, Seo MH, Fazelinia H, Maranas C, Kim HS

Enzyme and Microbial Technology

Enzyme Microb. Technol. 44, 170–175 (2009)

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2007

Optimization of critical factors affecting the performance of allergen chip for analysis of allergen-specific human IgE in serum

Han MK, Seo MH, Lee D, Kim S, Park HS, Kim HS

Analytical Sciences

Anal. Sci. 23(5), 545–549 (2007)

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